Stephen J Kron
Research Summary / Selected Publications
The Kron laboratory is a highly collaborative group of cell biologists, geneticists, biochemists and chemists. Our major basic research efforts are directed at 1) dissecting cyclin dependent kinase structure and function in yeast, 2) defining roles for chromatin modifications in DNA damage response, and 3) developing novel mass spectrometry methods for phosphoproteomics and high throughput screening. We also pursue translational projects directed at 1) developing Bcr-Abl assays for diagnostics and antagonists for therapeutics and 2) discovering inhibitors of cellular response to DNA double strand breaks as an approach to radiosensitization.
Post-doc inquiries are welcome! Please contact Dr. Kron at skron@uchicago.edu
The Kron laboratory is a highly collaborative group of cell biologists, geneticists, biochemists and chemists. Our major basic research efforts are directed at 1) dissecting cyclin dependent kinase structure and function in yeast, 2) defining roles for chromatin modifications in DNA damage response, and 3) developing novel mass spectrometry methods for phosphoproteomics and high throughput screening. We also pursue translational projects directed at 1) developing Bcr-Abl assays for diagnostics and antagonists for therapeutics and 2) discovering inhibitors of cellular response to DNA double strand breaks as an approach to radiosensitization.
Post-doc inquiries are welcome! Please contact Dr. Kron at skron@uchicago.edu
Parker L., Engel-Hall A., Drew K., Steinhardt G., Helseth Jr D.L., Jabon D., McMurry T., Angulo D.S. and Kron S.J. (2007). "Investigating quantitation of phosphorylation using MALDI-TOF mass spectrometry." J Mass Spectrom PubMed
Wysocki, R., Javaheri, A., Kristjansdottir, K., Sha, F. and Kron, S. J. (2006). "CDK Pho85 targets CDK inhibitor Sic1 to relieve yeast G1 checkpoint arrest after DNA damage." Nat Struct Mol Biol 13:908-914. PubMed Citation
Javaheri, A., Wysocki, R., Jobin-Robitaille, O., Altaf, M., Cote, J. and Kron, S. J. (2006). "Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling." Proc Natl Acad Sci U S A 103:13771-6.
PubMed Citation
Parker, L. L., Kurutz, J. W., Kent, S. B. and Kron, S. J. (2006). "Control of the yeast cell cycle with a photocleavable alpha-factor analogue." Angew Chem Int Ed Engl 45:6322-5. PubMed Citation
Wysocki, R., Javaheri, A., Allard, S., Sha, F., Cote, J. and Kron, S.J. (2005). "Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9."
Mol Cell Biol 25:8430-43. PubMed Citation
Parker, L.L., Schilling, A.B., Kron, S.J. and Kent, S.B. (2005). "Optimizing thiophosphorylation in the presence of competing phosphorylation with MALDI-TOF-MS detection." J Proteome Res. 4:1863-66. PubMed Citation
Wu, D., Nair-Gill, E., Sher, D.A., Parker, L.L., Campbell, J.M., Siddiqui, M., Stock, W. and Kron S.J. (2005). "Assaying Bcr-Abl kinase activity and inhibition in whole cell extracts by phosphorylation of substrates immobilized on agarose beads." Anal Biochem. 347:67-76. PubMed Citation
Downs, J. A., Allard, S., Jobin-Robitaille, O., Javaheri, A., Auger, A., Bouchard, N., Kron, S. J., Jackson, S. P. and Cote, J. (2004). "Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites." Mol Cell 16: 979-90. PubMed Citation
Wysocki, R. and Kron, S. J. (2004). "Yeast cell death during DNA damage arrest is independent of caspase or reactive oxygen species." J Cell Biol 166: 311-6. PubMed Citation
Parker L., Engel-Hall A., Drew K., Steinhardt G., Helseth Jr D.L., Jabon D., McMurry T., Angulo D.S. and Kron S.J. (2007). "Investigating quantitation of phosphorylation using MALDI-TOF mass spectrometry." J Mass Spectrom PubMed
Wysocki, R., Javaheri, A., Kristjansdottir, K., Sha, F. and Kron, S. J. (2006). "CDK Pho85 targets CDK inhibitor Sic1 to relieve yeast G1 checkpoint arrest after DNA damage." Nat Struct Mol Biol 13:908-914. PubMed Citation
Javaheri, A., Wysocki, R., Jobin-Robitaille, O., Altaf, M., Cote, J. and Kron, S. J. (2006). "Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling." Proc Natl Acad Sci U S A 103:13771-6.
PubMed Citation
Parker, L. L., Kurutz, J. W., Kent, S. B. and Kron, S. J. (2006). "Control of the yeast cell cycle with a photocleavable alpha-factor analogue." Angew Chem Int Ed Engl 45:6322-5. PubMed Citation
Wysocki, R., Javaheri, A., Allard, S., Sha, F., Cote, J. and Kron, S.J. (2005). "Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9."
Mol Cell Biol 25:8430-43. PubMed Citation
