Ira G Wool
Research Summary / Selected Publications
My research is dedicated to obtaining an understanding of the structure and the function of ribosomes. This encompasses the molecular biology of RNA and of protein synthesis. This includes studies of the atomic structure of rRNA domains, of the sequence of amino acids in ribosomal proteins, of the biochemistry of the partial reactions of protein synthesis, and the chemistry of RNA-protein and RNA-RNA interactions. In all of this the intention is to combine biochemistry, molecular genetics and structure.
My research is dedicated to obtaining an understanding of the structure and the function of ribosomes. This encompasses the molecular biology of RNA and of protein synthesis. This includes studies of the atomic structure of rRNA domains, of the sequence of amino acids in ribosomal proteins, of the biochemistry of the partial reactions of protein synthesis, and the chemistry of RNA-protein and RNA-RNA interactions. In all of this the intention is to combine biochemistry, molecular genetics and structure.
Yu, H., Chan, Y.L., & Wool, I,G. (2009). The identification of the determinants of the cyclic, sequential binding of elongation factors Tu and G to the ribosome. J. Mol. Biol. 386(3):802-813. link
Chan, Y.L. & Wool, I.G. (2008). The integrity of the sarcin/ricin domain of 23 S ribosomal RNA is not required for elongation factor-independent peptide synthesis. J. Mol. Biol. 378, 12-19. Link
Dresios, J., Chan, Y.L., & Wool, I.G. (2006). Determination of the amino acids in yeast ribosomal protein YS11 essential for the recognition of nucleotides in 18 S ribosomal RNA. J. Biol. Chem. 281, 13478-13484. Link
Chan, Y.L., Dresios, J., & Wool, I.G. (2006). A pathway for the transmission of allosteric signals in the ribosome through a network of RNA tertiary interactions. J. Mol. Biol. 355, 1014-1025. Link
Dresios, J., Chan, Y.L., & Wool, I.G. (2005). A determination of the identity elements in yeast 18 S ribosomal RNA for the recognition of ribosomal protein YS11: the role of the kink-turn motif in helix 11. J. Mol. Biol. 345, 681-693. Link
Chan, Y.L., Correll, C.C., and Wool, I.G. (2004). The location and the significance of a cross-link between the sarcin/ricin domain of ribosomal RNA and the elongation factor G. J. Mol. Biol. 337, 263-272. Link
Correll, C.C., Wool, I.G., & Munishkin, A. (1999). The two faces of the Escherichia coli 23 S rRNA sarcin/ricin domain: the structure at 1.11 Å resolution. J. Mol. Biol. 292, 275-287. Link
Correll, C.C., Munishkin, A., Chan, Y.L., Ren, Z., Wool, I.G., and Steitz, T.A. (1998). Crystal structure of the ribosomal RNA domain essential for binding elongation factors. Proc. Natl. Acad. Sci. USA 95:13436-13441. Link
Yu, H., Chan, Y.L., & Wool, I,G. (2009). The identification of the determinants of the cyclic, sequential binding of elongation factors Tu and G to the ribosome. J. Mol. Biol. 386(3):802-813. link
Chan, Y.L. & Wool, I.G. (2008). The integrity of the sarcin/ricin domain of 23 S ribosomal RNA is not required for elongation factor-independent peptide synthesis. J. Mol. Biol. 378, 12-19. Link
Dresios, J., Chan, Y.L., & Wool, I.G. (2006). Determination of the amino acids in yeast ribosomal protein YS11 essential for the recognition of nucleotides in 18 S ribosomal RNA. J. Biol. Chem. 281, 13478-13484. Link
Chan, Y.L., Dresios, J., & Wool, I.G. (2006). A pathway for the transmission of allosteric signals in the ribosome through a network of RNA tertiary interactions. J. Mol. Biol. 355, 1014-1025. Link
Dresios, J., Chan, Y.L., & Wool, I.G. (2005). A determination of the identity elements in yeast 18 S ribosomal RNA for the recognition of ribosomal protein YS11: the role of the kink-turn motif in helix 11. J. Mol. Biol. 345, 681-693. Link
