Molecular Genetics and Cellular Biology
Curriculum By Quarter

The course covers the physical-chemical phenomena that define protein structure and function. Topics include 1) the interactions/forces that define polypeptide confirmation; 2) the principles of protein folding, structure and design; and 3) the concepts of molecular motion, molecular recognition and enzyme catalysis. BCMB 30400,CHEM 32600,GENE 30400,HGEN 30400 Rice, Pan, Sosnick

Coverage of the fundamental tools of genetic analysis as used to study biological phenomena. A small number of organisms have been chosen for extensive study by biologists. The popularity of these organisms derives largely from the fact that their genomes can be easily manipulated, allowing sophisticated characterization of biological function. This course covers modern methods for genetic analysis in budding yeast, Drosophila, C. elegans, Arabidopsis, and the mouse. Case studies demonstrate how particular strengths of each system have been exploited to understand such processes as genetic recombination, pattern formation, and epigenetic regulation of gene expression.

Fundamental principles of genetics discussed in the context of current approaches to mapping and functional characterization of genes. The relative strengths and weaknesses of leading model organisms are emphasized via problem-solving and critical reading of original literature. BCMB 31400, GENE 31400,HGEN 31400 Bishop and staff

Fundamental principles of genetics discussed in the context of current approaches to mapping and functional characterization of genes. The relative strengths and weaknesses of leading model organisms are emphasized via problem-solving and critical reading of original literature. BCMB 31400, GENE 31400,HGEN 31400 Bishop and staff

Eukaryotic protein traffic and related topics, including molecular motors and cytoskeletal dynamics, organelle architecture and biogenesis, protein translocation and sorting, compartmentalization in the secretory pathway, endocytosis and exocytosis, and mechanisms and regulation of membrane fusion.

Eukaryotic protein traffic and related topics, including molecular motors and cytoskeletal dynamics, organelle architecture and biogenesis, protein translocationand sorting, compartmentalization in the secretory pathway, endocytosis and exocytosis,and mechanisms and regulation of membrane fusion. BCMB 31600, GENE 31600,HGEN 31600 Turkewitz, Glick

Eukaryotic protein traffic and related topics, including molecular motors and cytoskeletal dynamics, organelle architecture and biogenesis, protein translocationand sorting, compartmentalization in the secretory pathway, endocytosis and exocytosis,and mechanisms and regulation of membrane fusion. BCMB 31600, GENE 31600,HGEN 31600 Turkewitz, Glick

Lectures on current research by departmental faculty. A required course for all first-year graduate students BCMB 31900, GENE 31900, HGEN 31900, DVBI 31900 Staff

Lectures on current research by departmental faculty. A required course for all first-year graduate students BCMB 31900, GENE 31900, HGEN 31900, DVBI 31900 Staff

This course provides an overview of the fundamental questions of developmental biology, with particular emphasis on the modern genetic, molecular and cell biological experiments that have been employed to try to reach mechanistic answers to these questions. Topics covered will include mechanisms of primary body axis formation, the role of local signaling interactions in regulating cell fate and proliferation, plant development, and the cellular basis of morphogenesis. Emphasis will be placed on experimental approaches to understanding developmental processes, relevance to human disease, and exposure to the primary literature. BIOS 21227,DVBI 35400,GENE 35400 Ferguson, Preuss

Staff

Staff

Staff

The course covers nucleic acid structure and DNAtopology, recombinant DNA technology, DNA replication, DNA damage, mutagenesis and repair, Transposons and site-specific recombination, prokaryotic and eukaryotic transcription and its regulation, RNA structure, splicing and catalytic RNAs, protein synthesis, and chromatin.

The course covers nucleic acid structure and DNAtopology, recombinant DNA technology, DNA replication, DNA damage, mutagenesis and repair, Transposons and site-specific recombination, prokaryotic and eukaryotic transcription and its regulation, RNA structure, splicing and catalytic RNAs, protein synthesis, and chromatin. BIOS 21208,BCMB 31000, GENE 31000 Storb, Staley

The course covers nucleic acid structure and DNAtopology, recombinant DNA technology, DNA replication, DNA damage, mutagenesis and repair, Transposons and site-specific recombination, prokaryotic and eukaryotic transcription and its regulation, RNA structure, splicing and catalytic RNAs, protein synthesis, and chromatin. BIOS 21208,BCMB 31000, GENE 31000 Storb, Staley

Nucleic acid structure; mechanisms of transcription and replication. Regulation of transcription in prokaryotes, and of DNA replication in prokaryotes and eukaryotes.

Nucleic acid structure; methodology; nucleic-acid protein interactions; mechanisms of transcription and replication. Regulation of transcription in prokaryotes, and of DNA replication in prokaryotes and eukaryotes. BCMB 31200, GENE 31200, HGEN 31200 Rothman-Denes

Nucleic acid structure; methodology; nucleic-acid protein interactions; mechanisms of transcription and replication. Regulation of transcription in prokaryotes, and of DNA replication in prokaryotes and eukaryotes. BCMB 31200, GENE 31200, HGEN 31200 Rothman-Denes

Advanced coverage of genetic mechanisms involved in genome stability and rearrangement in lower and higher organisms. Topics include the genetics of mutagenesis, DNA repair, homologous and site specific recombination,transposition and chromosome segregation.

Advanced coverage of genetic mechanisms involved in genome stability and rearrangement in lower and higher organisms. Topics include the genetics of mutagenesis, DNA repair, homologous and site specific recombination,transposition and chromosome segregation. BCMB 31500,GENE 31500,HGEN 31500 Bishop, Ellis, Shapiro

Advanced coverage of genetic mechanisms involved in genome stability and rearrangement in lower and higher organisms. Topics include the genetics of mutagenesis, DNA repair, homologous and site specific recombination,transposition and chromosome segregation. BCMB 31500,GENE 31500,HGEN 31500 Bishop, Ellis, Shapiro

Lectures on current research by departmental faculty. A required course for all first-year graduate students BCMB 31900, GENE 31900, HGEN 31900, DVBI 31900 Staff

Lectures on current research by departmental faculty. A required course for all first-year graduate students BCMB 31900, GENE 31900, HGEN 31900, DVBI 31900 Staff

This course explores the use of genetics in three different model systems, C. elegans, Drosophila melanogaster and Arabodopsis thaliana, to elucidate developmental mechanisms. The class will focus on a series of interrelated topics: for each topic, introductory material presented by the lecturer will be followed by student-led discussions of individual papers. DVBI 35500, GENE 35500 Ferguson, Du, Greenberg

Topics include neural induction, early patterning of the central nervous system, axon guidance and neuronal migration, the development of brain activity, and the mechanisms of plasticity that fine-tune brain function. Approaches will range from molecular to cellular to systems neurobiology. Focus will be on the vertebrate CNS but attention will be given to important lessons from invertebrate systems. DVBI 35800, NURB 32500, BIOS 24207 Grove, Issa

Staff

Staff

Staff

Eukaryotic Gene Expression. Transcription and Posttranscriptional Regulation. Analysis of regulatory pathways and mechanisms involved in the control of eukaryotic gene activity.

Eukaryotic Gene Expression. Transcription and Posttranscriptional Regulation. Analysis of regulatory pathways and mechanisms involved in the control of eukaryotic gene activity. BCMB 31300, DVBI 31300, GENE 31300 Singh, Staley

Eukaryotic Gene Expression. Transcription and Posttranscriptional Regulation. Analysis of regulatory pathways and mechanisms involved in the control of eukaryotic gene activity. BCMB 31300, DVBI 31300, GENE 31300 Singh, Staley

Growth, differentiation and development in plants at the organismal, cellular, and molecular level. The regulatory function of environmental factors, hormones and phytochrome on gene expression and the possible evolutionary relationships will be studied. The molecular genetic advances in Arabidopsis and maize are a central feature of the course.

This course deals with the principles involved in obtaining electron micrographs of biological specimens. Preparation techniques and analytical procedures will be offered at an individualized level. Phys 30800 Josephs

This advanced-level course combines lectures, student presentations, and discussion sections.  It covers major topics in the developmental biology of vertebrate embryos (e.g., formation of the germ line, gastrulation, segmentation, nervous system development, limb patterning, organogenesis).   The course makes extensive use of the current primary literature and emphasizes experimental approaches including embryology, genetics, and molecular genetics. DVBI 35600, BIOS 21356 Millen

Staff

Staff

Staff

Staff

Staff

Staff