Statistical genetics, human population genetics, genetics of quantitative and complex phenotypes.
Structure and biochemistry of proteins involved in immunological recognition. Characterization of nonconventional T cells and their ligands and activating and inhibitory receptors involved in the immune response.
Structural, biochemical and functional studies of adhesion proteins on the cell membrane. Understanding how adhesion-type G-protein-coupled receptors function in the brain.
Genetics of diabetes and other metabolic disorders; development and regeneration of insulin-secreting pancreatic beta cells
Behavior and neuroscience of the nematode C. elegans; Sleep-like behavior of C. elegans.
A novel non-binary propagation pathway of plant mitochondria.
Biology and therapy of hemoglobinopathies, developmental biology of blood and neural crest, and stem cell research.
Studies sphingolipid signalling pathways and programmed cell death in brain and tumors. Focus on ceramide and the pathways it regulates such as PI3K. Use of quantum dots coated with chaperones as therapy vehicles for inherited lysosomal storage diseases resulting point mutations in Batten genes
Stress-triggered protein self-assembly, cellular stress responses, and molecular evolution.
Evolutionary and ecological functional genomics, with Hsp70 and other molecular chaperones in Drosophila as a focus.
Developmental genetics of cell fate specification and stem cell maintenance in Drosophila
Understanding gene regulatory processes and elucidating the genetic architecture of human-specific traits including disease.
I am interested in microbial ecology, especially the metabolic and signaling reactions between bacteria and their environment, and how communities of microorganisms establish in new environments.
Our group is generally focused upon identification of genetic determinants of common genetic disorders, with a particular emphasis on neurological and psychiatric genetic disease.
Biogenesis of secretory pathway organelles, and directed evolution of fluorescent proteins.
Molecular and cellular mechanisms of neurodegenerative disease — with a focus on the means by which genetic mutations in ion channels or other essential proteins lead to dominantly inherited neurodegenerative diseases.
Steroid hormone regulation of gene networks in reproductive tissues and cancers. Structure and function of nuclear receptors.
Biomedical informatics, data intensive computing, big data, data science, cloud computing, and related areas.
Cellular and molecular mechanisms that control patterning, cell fate choice, and differentiation in the mammalian forebrain.
Molecular biology of bone and soft tissue tumors; BMP and Wnt signaling in stem cells; Regulation of mesenchymal stem cell differentiation; Cancer drug resistance; Cancer microenvironment and bone metastasis; Gene therapy and regenerative medicine.
Regulation of gene expression by dynamic and reversible RNA modifications, epigenetic DNA methylation in various biological processes and human diseases.
Develop computational methods for analysis of genetic and genomic data, often in the context of human diseases.
Development and function of sensorimotor circuits for locomotion in Drosophila larvae
Collective cell migration and basement membrane remodeling during organ morphogenesis
Mouse models of human syndromes affecting morphogenesis, patterning, and cell fate during craniofacial and cardiovascular development.
Structure of sickle-cell hemoglobin fibers and the red cell cytoskeleton by cryoelectron microscopy and image reconstruction.
Molecular mechanisms of membrane protein biogenesis and quality control
Chemical protein synthesis. Application of chemistry to the study of proteins. Mechanism of enzyme catalysis.
Structure and function of hormone-receptor interactions, synthetic antibody technology, crystallization chaperones, drug delivery, phage display applications.
Biochemical and cellular mechanisms of actin cytoskeleton assembly, self-organization and maintenance.
Gene regulatory mechanisms required for C.elegans and mouse motor neuron development
Signal transduction, DNA damage checkpoints, cell cycle control, and epigenetics. Technology for proteomics, drug discovery and systems biology.
Chloroplast development; nuclear genes coding for chloroplast proteins; regulation of protein import and posttranslational processing.
Molecular analysis of recurring chromosomal abnormalities in human tumors; identification of cooperating mutations and genetic pathways leading to transformation.
New gene evolution: the rates and patterns, the impact of new genes on protein networks, the functional and phenotypic effects; Species- specific development and developmental evolution; other problems of genome evolution. Drosophila as experimental systems; in silico genomics of animals and plants.
Developmental genetics of oogenesis; ovarian germline stem cell; genetics of spermatogenesis.
Electron magnetic resonance; enzyme mechanisms; metalloenzymes; molecular dynamics; structural basis of enzyme action.
Phloem-mediated long distance signaling in plants.
Wound healing and regeneration in Cnidarians
Structure of cell nucleus; RNA transcription and processing; implications for the immune system; novel growth factors for tissue maintenance and differentiation.
Genomic analysis of blood cancers. Transcriptional regulation in development. Therapy of myeloid neoplasms.
Applications of probability and statistics to genetics; complex trait mapping; counting-process models for genetic recombination.
Protein aggregation and amyloid fibril structure; peptide synthesis; lipoprotein structure.
Time-resolved macromolecular crystallography; photoreceptors; design and engineering of light-sensitive proteins
Molecular genetics of cardiovascular development and congenital heart disease.
actomyosin network dynamics and contractility; cell polarization; tissue morphogenesis; computational cell and developmental biology
Genetics of heart development and congenital heart diseases. Genetic engineering of mouse models of human diseases. Genomic organization and gene regulatory architecture. Vertebrate comparative genomics.
Cancer genetics and epigenetics, molecular genetics of breast and ovarian cancer; genetics of cancer predisposition in diverse populations including BRCA1 and BRCA2 genes, inflammation and cancer.
To understand the genetic basis of cancer susceptibility with the ultimate objective of developing individualized cancer prevention strategies and targeted therapies.
Protein-Protein Interactions in the Extracellular Space; Structural Biology of Protein Receptor/Ligands Involved in Nervous System Development
Non-Coding RNA structure, function, and mechanism; RNA metabolism, engineering antibodies that bind RNA, imaging technology for RNA and cancer
Genetics of speciation, including molecular studies of gene flow, quantitative genetics of sexually selected traits, and comparative analyses using molecular phylogenies.
Molecular, cellular, and comparative study of vertebrate axial patterning using the zebrafish model.
Transcriptional regulatory circuitries in development and disease; Receptor tyrosine kinase signal transduction.
Our group studies fundamental problems in development, evolution, and transcriptional control using a combination of experiment, mathematics, and computation applied to the early <it>Drosophila<it> embryo.
Molecular and mechanisims regulating cancer cell colonization of metastatic sites. Our work includes the areas of signal transduction, stress kinase activation, cell cycle progression, and novel mechanisms regulating metastatic growth including quorum sensing.
Molecular motors; cytoskeletal organization; single-molecule biophysics
Growth factor receptor signaling leading to cell growth, cell differentiation or cell death.
Biophysical studies of the structure, dynamics and function of biological macromolecular systems.
parasite interactions; developmental aspects of gene expression.
Analysis of complex molecular networks for understanding common phenotypes
Transcriptional control of ECM expression during chondrogenesis and neurogenesis; regulation of sulfate activation; skeletal dysplasias.
Paleontology and developmental studies in salamanders to identify mechanisms behind the evolutionary origin of new anatomical features and faunas.
Protein and RNA/ribozyme folding; design of light-sensitive allosteric proteins; structure prediction, biological dynamics and thermodynamics as basis for understanding function.
Membrane cholesterol biochemistry and cellular cholesterol homeostasis.
Immunoglobulin gene expression; somatic hypermutation; regulation and functions of DNA methylation and chromatin modifications in development and transcription.
The Stranger lab is interested in human population genomics, specifically trying to understand how genetic and genomic variation contribute to human phenotypic variation.
Molecular mechanism of muscle contraction, nonmuscle actomyosin, cell motility, microfilaments, and microtubules
Secretory granules; exocytosis and endocytosis; evolution of membrane traffic.
Speciation, genomics, evolutionary genetics, molecular population genetics, sexual selection.