M.D, Federal University of Pernambuco, Recife, Brazil, 1995
Ph.D., Physiology and Molecular Genetics, Medical College of Wisconsin, 2001
Postdoctoral training, Genomics Division, Lawrence Berkeley National Lab., Berkeley, CA, 2001-2005
Our group is interested in dissecting the architecture and function of gene regulatory networks. We investigate how the multiple transcription activators, repressors, boundary elements connected to a gene interact and orchestrate the precise tissue-specific and temporal-specific expression pattern of that gene. Understanding this process is critical since it is thought that malfunction of the regulatory program of certain genes underlie the cause of several human diseases. We focus on heart development and congenital heart diseases as substrates to test our hypotheses, and we use mouse and zebrafish genetic engineering, comparative genomics, bioinformatics and other high throughput genomic screening and validation strategies as experimental tools.